5 ESSENTIAL ELEMENTS FOR METHADONE MAINTENANCE TREATMENT

[sixty one] Like lots of other cardiotoxic drugs, methadone blocks the hERG K+ channel. The 2 enantiomers of methadone inhibit hERG channels with various potency. Dextromethadone, that's much less strong as an opioid, is more powerful at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone incorporates a lower affinity, with an IC50 of